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Arul M Chinnaiyan Selected Research

Chromatin

4/2024Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer.
3/2024p300/CBP degradation is required to disable the active AR enhanceosome in prostate cancer.
3/2024Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer.
3/2024NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis.
1/2024Targeting the mSWI/SNF Complex in POU2F-POU2AF Transcription Factor-Driven Malignancies.
1/2023Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways.
1/2022Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer.
2/2021De novo neuroendocrine transdifferentiation in primary prostate cancer-a phenotype associated with advanced clinico-pathologic features and aggressive outcome.
1/2021A proteogenomic portrait of lung squamous cell carcinoma.
1/2020Epigenetic driver mutations in ARID1A shape cancer immune phenotype and immunotherapy.
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Arul M Chinnaiyan Research Topics

Disease

274Neoplasms (Cancer)
04/2024 - 01/2002
231Prostatic Neoplasms (Prostate Cancer)
04/2024 - 04/2002
33Neoplasm Metastasis (Metastasis)
10/2023 - 09/2002
31Breast Neoplasms (Breast Cancer)
01/2023 - 01/2002
21Carcinoma (Carcinomatosis)
04/2021 - 01/2003
16Carcinogenesis
03/2022 - 01/2003
13Disease Progression
03/2024 - 07/2003
12Adenocarcinoma
01/2023 - 01/2003
11Renal Cell Carcinoma (Grawitz Tumor)
02/2024 - 07/2002
10Lung Neoplasms (Lung Cancer)
07/2020 - 04/2007
7Prostatic Intraepithelial Neoplasia
08/2012 - 04/2002
6Melanoma (Melanoma, Malignant)
02/2024 - 07/2002
6Glioma (Gliomas)
01/2023 - 11/2016
6Leukemia
02/2020 - 09/2009
5Brain Neoplasms (Brain Tumor)
01/2023 - 10/2017
5Urinary Bladder Neoplasms (Bladder Cancer)
01/2022 - 05/2009
5Glioblastoma (Glioblastoma Multiforme)
10/2020 - 06/2003
5Adenocarcinoma of Lung
01/2017 - 04/2007
5Prostatic Hyperplasia (Benign Prostatic Hyperplasia)
09/2009 - 02/2005
4COVID-19
01/2023 - 01/2021
3Pancreatic Neoplasms (Pancreatic Cancer)
03/2024 - 06/2003
3Ependymoma
01/2023 - 11/2016
3Merkel Cell Carcinoma
01/2022 - 09/2017
3Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2021 - 01/2013
3Squamous Cell Carcinoma of Head and Neck
01/2021 - 11/2011
3Lymphoma (Lymphomas)
01/2021 - 07/2002
3Tuberous Sclerosis (Bourneville's Disease)
05/2020 - 10/2018

Drug/Important Bio-Agent (IBA)

87Proteins (Proteins, Gene)FDA Link
04/2024 - 04/2002
81Biomarkers (Surrogate Marker)IBA
04/2024 - 04/2002
68RNA (Ribonucleic Acid)IBA
04/2024 - 11/2002
46AndrogensIBA
12/2023 - 06/2004
40DNA (Deoxyribonucleic Acid)IBA
01/2023 - 01/2002
39Androgen Receptors (Androgen Receptor)IBA
04/2024 - 06/2005
29Prostate-Specific Antigen (Semenogelase)IBA
04/2024 - 05/2003
25Transcription Factors (Transcription Factor)IBA
04/2024 - 06/2005
25Hormones (Hormone)IBA
01/2021 - 09/2002
18Long Noncoding RNAIBA
09/2023 - 07/2011
18Messenger RNA (mRNA)IBA
01/2021 - 04/2002
17ChromatinIBA
04/2024 - 08/2007
14Proto-Oncogene Proteins c-etsIBA
12/2016 - 10/2005
14Complementary DNA (cDNA)IBA
06/2011 - 08/2002
13Phosphotransferases (Kinase)IBA
03/2024 - 01/2003
12enzalutamideIBA
04/2024 - 01/2016
10Histones (Histone)IBA
04/2024 - 02/2012
10AntigensIBA
01/2022 - 12/2002
10Kazal Pancreatic Trypsin InhibitorIBA
01/2022 - 02/2008
9Estrogen ReceptorsIBA
01/2022 - 12/2005
9MicroRNAs (MicroRNA)IBA
01/2016 - 01/2010
9alpha-methylacyl-CoA racemaseIBA
06/2005 - 07/2002
8Serine Proteases (Serine Protease)IBA
01/2021 - 06/2008
7snake venom protein C activatorIBA
04/2024 - 09/2023
7EnzymesIBA
01/2016 - 04/2002
6Lysine (L-Lysine)FDA Link
04/2024 - 01/2023
6Adenosine Triphosphatases (ATPase)IBA
04/2024 - 01/2022
6Immune Checkpoint InhibitorsIBA
03/2024 - 01/2021
6Phenobarbital (Luminal)FDA Link
03/2024 - 05/2012
6AntibodiesIBA
01/2018 - 12/2002
6Estrogens (Estrogen)FDA Link
11/2016 - 01/2006
6AutoantibodiesIBA
11/2008 - 05/2005
5LigandsIBA
01/2022 - 10/2004
5Polycomb-Group ProteinsIBA
01/2019 - 10/2002
5Enhancer of Zeste Homolog 2 ProteinIBA
01/2019 - 10/2002
5ErbB Receptors (EGF Receptor)IBA
04/2015 - 01/2004
5Tumor Biomarkers (Tumor Markers)IBA
11/2014 - 07/2002
5Peptides (Polypeptides)IBA
10/2014 - 09/2005
4MethyltransferasesIBA
04/2024 - 01/2016
4Small Cytoplasmic RNAIBA
04/2024 - 01/2021
4Cyclin-Dependent Kinases (cdk Proteins)IBA
03/2024 - 01/2020
4purineIBA
01/2022 - 09/2015
4Tumor Viral Antigens (Large T Antigen)IBA
01/2022 - 09/2008
4Protein Isoforms (Isoforms)IBA
01/2022 - 02/2005
4Progesterone Receptors (Progesterone Receptor)IBA
01/2021 - 12/2005
4Succinate Dehydrogenase (Fumarate Reductase)IBA
05/2020 - 06/2017
4ElementsIBA
01/2019 - 04/2004
4Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
01/2019 - 05/2011
4Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
11/2017 - 09/2004
4Glycine (Aminoacetic Acid)FDA LinkGeneric
01/2017 - 02/2009
4Sarcosine (Methylglycine)IBA
01/2017 - 02/2009
4ProteomeIBA
01/2013 - 12/2003
4Fatty Acids (Saturated Fatty Acids)IBA
11/2011 - 03/2004
45' Untranslated Regions (5' UTR)IBA
11/2009 - 10/2005
4Neoplasm Antigens (Tumor Antigens)IBA
11/2008 - 06/2004
4Cadherins (E-Cadherin)IBA
04/2008 - 01/2003
3LipidsIBA
03/2024 - 12/2019
3CytokinesIBA
12/2023 - 01/2002
3CateninsIBA
01/2023 - 03/2014
3Fumarate Hydratase (Fumarase)IBA
01/2023 - 06/2017
3Phosphoric Monoester Hydrolases (Phosphatases)IBA
01/2023 - 02/2013
3InterferonsIBA
01/2023 - 01/2002
3TamoxifenFDA LinkGeneric
01/2022 - 01/2008
3Programmed Cell Death 1 ReceptorIBA
01/2021 - 01/2018
3Tyrosine Kinase InhibitorsIBA
01/2021 - 09/2004
3Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
01/2021 - 04/2006

Therapy/Procedure

90Therapeutics
04/2024 - 04/2002
46Castration
04/2024 - 07/2010
23Prostatectomy (Retropubic Prostatectomy)
01/2022 - 05/2003
11Immunotherapy
03/2024 - 09/2008
11Precision Medicine
01/2023 - 05/2013
9Drug Therapy (Chemotherapy)
03/2024 - 09/2004
9Radiotherapy
12/2023 - 10/2002